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Supporting this pathway, fecal samples from stress-induced depression models to healthy mice induces hippocampal neurogenesis deficits and neuroinflammation, whereas these effects are abolished after vagotomy (Siopi et al., 2023)

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That third target is the whole story of why retatrutide is being studied, and understanding it is the key to reading the trial numbers correctly

The Bridge program launched July 1, 2026, and is scheduled to run through Dec